Cibenzoline对山羊持续性心房颤动蝉联现象的影响

Effect of cibenzoline on linking phenomenon in chronically instrumented goat model

摘要: 目的: 分析Ic类抗心律失常药cibenzoline对心房颤动(房颤)时蝉联现象的影响。方法: 在7只山羊的心房缝合心外膜电极,用自动房颤刺激器维持房颤,待持续性房颤维持4周后,静脉滴注cibenzoline转复房颤。根据激动标测图分析左心房用药前及后蝉联心搏占总心搏数的比例并分析蝉联片段激动方向的规律。结果: 用药前连续7次循相同路径的激动占(9 6±1 5 3)%,在房颤转复前为(30.7±2 6.2)%(P<0.05);用药前后共有27个蝉联片段,其激动方向相互垂直的1(3.7%)次,成45°角的2(7.4%)次,一致或相反的23(85.2%)次(P<0.05)。结论: I类抗心律失常药cibenzoline可增加房颤时蝉联心搏的比例,蝉联片段的方向多一致或相反。

Abstract: Objective: To evaluate the effect of Ic antiarrhythmic drug cibenzoline on linking phenomenon in persistent atrial fibrillation goat model. Methods: Seven goats were instrumented with atrial electrodes.AF was maintained by an automatic atrial fibrillator.After 4 weeks of persistent AF,cibenzoline was infused until cardioversion,linking phenomenon in left atrium was studied. Results: There were (9.6±15.3)% beats belong to linking episodes before drug infusion,and they were (30.7 ±26.2)% (P<0.05)before cardioversion. Conclusion: It was found that cibenzoline increased the percentage of linked beats during AF.