Abstract: Objective To provide the decision-making evidence for the security of intravenous fluids infusion and nursing of patients by analyzing the application of intravenous fluid infusion in our hospital. Methods Intravenous fluid infusion in 130 nursing units of 53 department in our hospital was investigated with questionnaire designed for intravenous fluid infusion with cross-sectional investigation method. Results A total of 735 patients in 25 nursing units were investigated.The intravenous fluid infusion rate was 88.9%（653/735）.No significant difference was found in intravenous fluid infusion between age of patients and treatment modality.The utilization rate of trocars and PICC was 37.4% and 37.0%,respectively.PICC was mainly used in tumor patients receiving chemotherapy.The incidence of complications in intravenous fluid infusion was 4.9%. Conclusion Intravenous fluid infusion is widely applied in clinical practice due to its advantages of multiple approaches and long-term dwelling.Training of nurses taking the charge of intravenous fluid infusion should be strengthened in rational use of intravenous infusion catheter in order to reduce its complications.