无精和严重寡精症中无精子症因子基因的初步研究

Studies on YRRM gene in azoospermia and severe oligospermia

摘要: 目的: 研究无精子症因子基因与无精症的关系。方法: 利用聚合酶链反应对74例原发无精和严重寡精患者进行YRRM基因的扩增检查,同时利用男性性别决定的SRY基因片段作为内参照系统。结果: 在检查的74例病例中,共有4例的YRRM基因位点没有扩增信号。结论: 提示这些个体带有YRRM的缺失异常,与无精所致的不育直接相关

Abstract: Objective: Study the relationship between the AZF gene and azoospermia. Methods: Using the PCR method, we analyzed YRRM gene （the candidates gene for AZF, Azoospermia Factor） from 74 Chinese men with either azoospermia or severe oligospermia. The SRY gene was used for internal control. Results: 4 of 74 men have no amplification band in the YRRM gene. Conclusion: It suggested that these case with abnormal YRRM gene may be result in the male infertility.