MED19 (LCMR1) 基因在肿瘤中的表达及生物学功能的研究进展

刘鹿; 陈良安

doi:10.3969/j.issn.2095-5227.2023.04.018

MED19 (LCMR1) 基因在肿瘤中的表达及生物学功能的研究进展

doi: 10.3969/j.issn.2095-5227.2023.04.018

刘鹿^{1, 2,},
陈良安^3, ,

1.
解放军医学院，北京　100853
2.
解放军总医院第一医学中心营养科，北京　100853
3.
解放军总医院第八医学中心呼吸与危重症医学部，北京　100853

基金项目: 军委科学技术委员会国防科技项目(2021-JCJQ-ZD-077-12)

详细信息

作者简介:
刘鹿，女，硕士，主治医师。Email: deer_3016@163.com

通讯作者:
陈良安，男，博士，主任医师，教授。Email: lianganchen301@263.net

中图分类号: R737.9
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- 文章访问数: 79
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- 被引次数: 0
出版历程
- 收稿日期: 2022-06-22
- 网络出版日期: 2023-03-21
- 刊出日期: 2023-04-28

Research advances in expression and biological function of MED19 in tumor

LIU Lu^{1, 2
,},
CHEN Liang'an^{3
, ,}

1.
Chinese PLA Medical School, Beijing 100853, China
2.
Department of Nutrition, the First Medical Center, Chinese PLA General Hospital, Beijing 100853, China
3.
Department of Pulmonary and Critical Care Medicine, the Eighth Medical Center, Chinese PLA General Hospital, Beijing 100853, China

More Information

Corresponding author: CHEN Liang'an. Email: lianganchen301@263.net

摘要

摘要: 中介体复合物(mediator complex subunit，MED)是广泛存在于酵母和哺乳动物体内的一种高度保守的多蛋白体复合物，参与转录因子与RNA聚合酶Ⅱ(RNA polymerase Ⅱ，RNA pol-Ⅱ)间的信息传递过程。MED19作为人中介体复合物的亚基之一，与人生长发育，尤其是肿瘤发生发展密切相关。本文对人MED19基因的结构和生物学功能研究进展进行综述，为后续MED19研究提供依据与思路。
- 中介体复合物 /
- LCMR1 /
- MED19 /
- 肿瘤
Abstract: Mediator complex subunit (MED) is a highly conserved multiprotein complex which is widely existing in yeast and mammals, and it is involved in the information transfer process between transcription factors and RNA pol-II. As one of the subunits of human mediator complex, MED19 is closely related to human growth and development, especially to tumorigenesis and development. In this paper, the research advances in the structure and biological function of human MED19 will be reviewed to provide ideas for subsequent research on MED19.
- mediator complex /
- LCMR1 /
- MED19 /
- tumor

HTML全文

表 1 MED19与肿瘤发展的可能相关信号通路汇总

Table 1. Possible signaling pathways associated with MED19 and tumor development

肿瘤类型	相关信号通路	研究类型	研究结论
肝癌	AKT/mTOR^[16]	体外研究	下调MED19降低p-AKT和p-mTOR表达
乳腺癌	HMGB1^[21]	体外研究	下调MED19降低人乳腺癌细胞自噬
乳腺癌	EGFR/MEK/ERK^[22]	组织标本	被miR-101-3p/miR-422a靶向促进乳腺癌进展，与EGFR表达呈正相关
膀胱癌	Wnt/β-catenin^[30]	体外研究	下调MED19诱发通路活性降低
喉癌	Caspase-3/9/Apaf-1^[37]	体外研究	下调MED19诱导喉癌细胞凋亡
脑胶质瘤	Wnt/β-catenin^[38]	数据分析	潜在靶向基因影响总体生存预后

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