+Gz对颞下颌关节影响的动物实验模型

An animal model for the study on effects of repeated +Gz forces on temporomandibular joint

摘要: 目的: 建立持续性高加速度(+Gz)重复作用下颞下颌关节变化的动物模型。方法: 将雄性Wistar大鼠随机分成3组,对照组、+1Gz组和+10Gz组,每组12只。应用六九型动物离心机,离心加速度曲线为梯形,+10Gz峰值持续时间为30s,G值增长率约为0 5G/s,间隔+1Gz 6 0s,连续每天5次,每周4d,共3周。结果: 在实验中大鼠能逐渐适应固定和持续性高加速度(+Gz)重复作用,同时,成功地复制出颞下颌关节疾病的病理表现。结论: 本动物模型重复性好,是研究正加速度对颞下颌关节影响比较理想的动物模型。

Abstract: Objective: To analysis the effects of repeated +Gz forces on the temporomandibular joint（TMJ）, an animal model was established..Methods: 36 male Wistar rats were randomly divided into 3 groups, control group, +1Gz group, and +10Gz group.The control group was only fixed with rat-kept devices for 5 minutes.The +1Gz group was borne +1Gz for 5 minutes.The +10Gz group was repeatedly exposed +10Gz(each for 30s, onset rate about 0.5G/s, 5 times/d with +1Gz 1 minute intervals, 4d/wk, 3 Weeks in total..Results: The behaviors of these rats were described in details and pathologic injuries in TMJ were produced..Conclusion: The animal model, which has good repeatition and induces pathologic changes in different degrees under various experimental variables, is a perfect model to observe the effects of repeated +Gz stresses on TMJ.