Abstract: Objective To compare the cleaning effects of 3 enema preparations before laparoscopic operation in gynecology. Methods Three hundred patients who were going to undergo laparoscopic operation in gynecology were randomly divided into group A undergoing enema with oral polyethylene glycol electrolyte powder（n=100）,group B undergoing enema with oral mannitol（n=100）,and group C undergoing enema with oral magnesium sulfate（n=100）.Adverse reaction rate,defecation frequency,first defecation and exsufflation time of the patients were recorded after operation. Results The adverse reaction rate was lower in group A（15%） than in groups B（32%） and C（36%）,the number of defecation frequencies was greater in group B than in groups A and C,and the first exsufflation and defecation time were lower in group A than in groups B and C after operation（P＜0.05）. Conclusion Polyethylene glycol electrolyte solution can be used in preparation of bowls before laparoscopic operation in gynecology with a satisfactory cleaning effect,few adverse effects,and an exsufflation-promoting effect.