Abstract: Objective To establish an stable experimental model of chronic atrophic gastritis（CAG） in rats and investigate the effect on the liver preliminarily by stimulating rat gastric mucosa with multiple factors. Methods Rats were randomly divided into model group and normal control group.Rat in model group had free access to 0.1% ammonia water and drank a mixture of 2% sodium salicylate and 30% alcohol for the first 10 weeks followed by 20mmol/L sodium deoxycholate for the next 12 weeks,while those in normal group had free access to drinking water for 22 weeks. Results The general condition was worse,the body weight gain was slower,the atrophy of glands was more significant,the mucosa was thinner,the muscular layer of mucosa was thicker,and the infiltration of inflammatory cells was severer in model group than in normal control group.No intestinal metaplasia and dysplasia,and no obvious abnormality of liver pathology were observed in two groups. Conclusion A CAG model is successfully established by stimulating gastric mucosa with multiple factors,with no obvious effect on liver pathology.