Abstract: Objective: To explore the change and implication of plasma brain natriuretic peptide（BNP） concentrations in patients with hypertension. Methods: 31 patients with hypertension and 20 normal controls（NC） were selected in this study.The plasma BNP concentrations was determined by solid-phase immunoradiometric assay.Left ventricular diastolic function and left ventricular end-diastolic pressure（E/Em） were studied using Doppler echocardiography and tissue Doppler imaging（TDI）. Results: The plasma BNP concentrations in 31 patients with hypertension was higher than those in NC group（P＜0.01）.②Compared with NC group,LAD、IVS、LVPW increased,E/A ratio decreased significantly while peak velocity A and E/Em ratio increased significantly in hypertension group（P＜0.01）. Conclusion: Plasma BNP level was elevated in 36 patients with hypertension.Plasma BNP levels in patients with hypertension may be a useful measure of Ventricular structural and functional alterations.