Abstract: Objective To observe the effect of NaHS and H₂S on the cardiac function of rats with heart failure due to stricture of abdominal aorta. Methods Sixty-three male SD rats were divided into control group,heart failure（HF）group and NaHS group.Rats in the HF and NaHS groups underwent surgery for abdominal aorta stricture,rats in the control group received sham operation.Three weeks after operation,rats in the NaHS group were intra-peritoneally injected with NaHS（56μmol/kg）once a day for 12 weeks,rats in the control and HF groups were injected with an equal volume of saline.Caudal arterial blood pressure（BP）and hemodynamic performance of all rats were measured 4,8 and 12 weeks after injection of NaHS and saline. Results The BP,mean BP（MBP）,left ventricular pressure（LVSP）and left ventricular end-diastolic pressure（LVEDP）were significantly decreased while the LV±dp/dpmax were obviously increased in NaHS group 12 weeks after injection of NaHS. Conclusion Cardiac functions and hemodynamics of rats with heart failure due to overload of pressure can be improved by intra-peritoneal injection of NaHS.