金力源胶囊对大鼠血脂调控作用的研究

Study of the blood lipid regulation of Jinliyuan capsules on experimental hyperlipidemia rates

  • 摘要: 目的: 观察金力源胶囊对高脂血症大鼠血脂的调节作用,为开发防治高脂血症的中药提供实验依据。方法: W istar大鼠60只按体重随机分为普通饲料组、高脂模型组,按剂量金力源分别为高剂量组(4g/kg)、中剂量组(2g/kg)、低剂量组(0.8g/kg)、和力平之对照组。于实验后第12周测定大鼠血清总胆固醇(Ch)、甘油三脂(Tg)及高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)。结果: 与高血脂模型组相比,金力源各组大鼠体重和肝体重比例均显著降低(P<0.05),血清Ch,Tg,LDL-C含量均显著降低(P<0.05),HDL-C含量无显著变化。结论: 金力源对实验性高血脂大鼠有明显的降血脂效应,使实验大鼠的Ch、Tg和LDL-C显著降低,而且能显著减轻实验大鼠的体重和肝体重比例。

     

    Abstract: Objective:To study the anti-hyperlipidemia effect of Jinliyuan capsules(JLY) on experimental hyperlipidemia rates.Methods:60 male Wistar rats were randomly divided into six groups.They were fed with normal diet,high lipid diet,high lipid diet with different concentration JLY(4g/kg,2g/kg,0.8g/kg),high lipid diet with Lipingzhi capsules,respectively.The body weight were measured weekly.After 12 weeks,the serum Ch, Tg,HDL-C,LDL-C and liver weight were measured.(Results:The) data showed that JLY could significantly lower body weight,the ratio of liver weight/body weight and serum Ch,Tg,LDL-C level of experimental hyperlipidemia rates,but has no significant effect on serum HDL-C.Conclusion:JLY has potential regulation function on lipid metabolism.

     

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