阻塞性睡眠呼吸暂停综合征患者炎症因子水平与合并高血压病关系的研究

Correlation between interleukin level and hypertension in obstructive sleep apnea syndrome patients

摘要: 目的: 观察OSAS患者体内炎症因子的水平与OSAS合并高血压的关系。方法: 用PSG检查诊断重度OSAS患者60例,其中32例合并高血压病。用ELISA方法检测OSAS患者血清中TNF-α、IL-6、IL-10的水平。结果: OSAS合并高血压患者TNF-α和IL-6水平均显著高于OSAS患者和正常对照组,而IL-10水平在三组中的水平呈逐渐降低,OSAS合并高血压患者IL-10水平低于OSAS患者和正常对照组。结论: 同等严重程度的OSAS患者体内细胞因子水平并不相同,这种差异在高血压的形成方面可能具有重要作用。

Abstract: Objective: To observe the correlation between interleukin level and hypertension in patients with obstructive sleep apnea syndrome（OSAS）. Methods: OSAS was diagnosed with PSG method and serum levels of TNF-α,IL-6,IL-10 were measured by ELISA. Results: The serum levels of TNF-α and IL-6 were higher in OSAS patients with hypertension than in those without hypertension.However,the serum level of IL-10 was lower in OSAS patients with hypertension than in those without hypertension. Conclusion: The interleukin levels are different in severe OSAS patients,which may play a role in the development of hypertension in OSAS patients.