肺癌患者血清ProGRP、CA125、CYFRA<sub>21-1</sub>和TPS检测的临床意义

肺癌患者血清ProGRP、CA125、CYFRA_21-1和TPS检测的临床意义

摘要: 目的: 探讨血清肿瘤标志物ProGRP、CA125、CYFRA_21-1和TPS在肺癌诊断中的价值。方法: 回顾性分析180例患者的临床资料和肿瘤标志物水平,评价肿瘤标志物与肺癌的关系。结果: 肺癌组患者ProGRP、CA125、CYFRA_21-1和TPS阳性率明显高于肺部良性病变组,三项或四项联合检测敏感性和特异性明显优于单项检测。结论: ProGRP、CA125、CYFRA_21-1和TPS中至少三项联合检测可提高肺癌诊断的敏感性和特异性。

Abstract: Objective: To evaluate the clinical value of tumor markers of ProGRP,CA125,CYFRA_21-1 and TPS in the diagnosis of lung cancer. Methods: The serum levels of tumor markers and clinical data of 180 patients were reviewed retrospectively. Results: The positive rates of ProGRP,CA125,CYFRA_21-1 and TPS were higher in lung cancer group than those in benign lung diseases group respectively.The sensitivity was obviously higher by combined measurement of ProGRP,CA125,CYFRA_21-1 and TPS than that only by one tumor marker assay. Conclusion: The diagnostic sensitivity and specificity of lung cancer were raised by combined measurement of ProGRP,CA125,CYFRA_21-1 and TPS.