Abstract: Objective:To investigate the effect of CDA-II on the expression of ICAM-1 of breast cancer cells.Methods:The effect of CDA-II on growth curve,expression of ICAM-1 and morphology of breast carcinoma cell lines MCF-7 and MDA-MB-231 were observed in vitro cultures,in comparison with the classical cell differentiation inducer ATRA.MCF-7 and MDA-MB-231 have their different biologic characteristics.Results:CDA-II can reduce the growth speed,proliferation ability and induce ICAM-1 expression of breast cancer cell lines.Conclusion:CDA-II has remarkable effect of anti-cell-proliferation and can increase expression of ICAM-1 on breast cancer cells.Our results provide experimental bases for the treatment of breast carcinoma with CDA-II and also suggest that CDA-II showed good prospects of application for the treatment of breast carcinoma.