Abstract: Objective To assess the feasibility of transurethral plasma kinetic enucleation of prostate(TUPKEP) for benign prostatic hyperplasia(BPH) by comparing changes in interleukin-6(IL-6) and C reactive protein(CRP) before and after different surgical procedures. Methods Sixty-four patients with BPH were included in this study.Of these patients,16 who underwent transurethral vapor-resection of the prostate(TUVP) served as TUVP group and 48 who underwent TUPKEP with the British Gyrus-PKS system served as TUPKEP.Their serum IL-6 and CRP levels were measured 2h before operation and 24 and 48h after operation by ELISA. Results No significant difference was found in serum IL-6 level between the two groups before operation(P>0.05).However,the serum IL-6 level was significantly higher in the patients after operation than before operation(P<0.05).The serum IL-6 level was significantly higher in TUVP group than in TUPKEP group 24 and 48h after operation((3.86±1.42)μg/L vs(2.27±1.15)μg/L,(1.07±1.03)μg/L vs(0.81±1.24)μg/L,P<0.05).No significant difference was found in serum CRP level in the patients before operation(P>0.05).However,the serum CRP level was significantly higher in the patients after operation than before operation(P<0.05).The serum CRP level was significantly higher in the TUVP group than in the TUPKEP group 24 and 48 h after operation((41.54±12.88)mg/L vs(30.29±10.14)mg/L,(72.57±16.85)mg/L vs(58.29±11.56)mg/L,P<0.05). Conclusion TUPKEP is more suitable than TUVP to BPH with less damages.