Abstract: Objective To investigate the clinicopathologic features,immunotype,differential diagnosis and prognosis of renal mucinous tubular and spindle cell carcinoma（MTSCC）. Methods Clinicopathological features and immunotype of a patient with MTSCC were studied and its related literatures were reviewed. Results The patient,a female at the age of 41 years,was admitted to our hospital due to a 2-week history of painless hematuria on May 18,2007.She was diagnosed having renal cancer measuring 3cm×2cm×2cm,which was then resected.The tumor was well-defined with a gray and soft cut surface.Cord,tubular and fascicular structures were observed under a microscope in the tumor.Tumor cells were cuboidal and spindle in shape with no significant atypia and mitosis.Tumor cells could express CKpan,CK7,P504S,and Vimentin. Conclusion MTSCC is a rare tumor with a low-grade malignance and should be differentiated from other renal cell carcinomas.