Abstract: In this report,the diagnosis and treatment of 8 patients with Wegener’S granulomatosis（WG）were described.The characteristic pathological changes of this disease were inflammatory cellular infiltration of the vessel wall combined with necrotizing granulomatous features.The chief clinical manifestations were as follows:fever（39～40℃）,nasal obstruction,epistaxis,cough with bloody sputum,mucosal ulceration in the mouth,nose or nasapharynx and subcutaneous nodules.X-ray films showed multiple nodular infiltrations with cavitary formation in the lung fields and signs of paranasal sinusitis.The diagnosis of WG depended mainly on tissue biopsy of different parts of the body.Cyclophospharnide in combination with glucocorticoid.were used to treat WG with excellent effects.