Abstract: The prevalence of tic disorders in children is gradually increasing, often accompanied by comorbidities, which can have a significant impact on their psychological well-being and daily life. The etiology of tic disorders remains unclear, although current mainstream theories suggest the involvement of neurobiochemical factors in their development. In recent years, with the emergence of the concept of microbiota-gut-brain axis, it has been proposed that the microbiota plays a role in regulating the occurrence of various neurological disorders, including tic disorders. This article summarizes the regulatory role of microbiota-gut-brain axis in tic disorders and provides an overview of the progress in the use of microbiota-related preparations for tic disorders treatment, aiming to promote further research on the pathogenesis and treatment strategies for tic disorders.