Abstract: The intestinal mucosal barrier is the body's first line of defense against harmful antigens in the intestinal lumen. Damage to the intestinal mucosal barrier can result from various factors such as ischemia, hypoxia, physical and chemical immunity, changes in intestinal flora, and oxygen-free radicals. Zinc is a crucial trace element that regulates mucosal integrity by reducing intestinal damage, exerting anti-inflammatory effects, and rebuilding the intestinal microbiota. By modulating the NF-κB signaling pathway, zinc can reduce intestinal damage, counter inflammation, and reconstruct the intestinal microbiota to regulate mucosal integrity, thereby repairing intestinal mucosal damage, which provides reference for the study of the mechanisms of zinc agents in repairing intestinal mucosal barrier damage.