Abstract: Pancreatic divisum is the most common congenital abnormality of pancreatic development, and most patients are asymptomatic. However, a small percentage of patients may develop clinical symptoms such as pancreatitis and chronic abdominal pain, known as symptomatic pancreatic divisum. In recent years, with the development of medical imaging and endoscopic techniques, the diagnosis and treatment of pancreatic divisum have made remarkable progress. Non-invasive diagnostics have become possible, and the concept of "ultra-minimally invasive" treatments has become increasingly popular. Despite the increasing level of diagnosis and treatment of pancreatic divisum, there are still challenges and problems in clinical practice that require further study and investigation. In this paper, the progress of diagnosis and endoscopic therapy of pancreatic divisum is reviewed in order to deepen the understanding of pancreatic divisum and improve the ability of clinical diagnosis and treatment.