Abstract: Objective To provide reference for the diagnosis,recognition,prevention,treatment and medical assessment of mental disorders manifested as body disorder by reporting the disorder in 3 pilots. Methods Clinical data about the 3 pilots admitted to our hospital in March 2010,November 2011 and February 2012 respectively were analyzed with related literature reviewed. Results The 3 pilots,manifested as body disorders such as enterospasm,hypertension and ischemic heart disease,were finally diagnosed as mental disorders such as somatoform disorder,post-traumatic stress,and panic disorder.Of these 3 pilots,1 returned to flight,1 could be expected to return to flight,and 1 was difficulty to return to flight due to poor therapeutic outcome after general mental therapy. Conclusion Misdiagnosis and unreasonable treatment of mental disorder in pilots can be reduced by strengthening mental intervention and improving understanding of mental disorders.