冠心病合并代谢综合征患者的脂质和载脂蛋白水平分析

李伟聪; 何昆仑; 武强

doi:10.3969/j.issn.2095-5227.2013.06.010

冠心病合并代谢综合征患者的脂质和载脂蛋白水平分析

Serum levels of lipid and apolipoprotein in coronary heart disease patients with metabolic syndrome

摘要

摘要: 目的对冠心病合并代谢综合征(metabolic syndrome，MS)的患者脂质和载脂蛋白水平进行分析。方法选择于2011年5月-2012年10月在我院心内科行冠状动脉造影术并确诊为冠心病的患者119例，分为合并MS组(53例)和未合并MS组(66例)，比较两组相关危险因素，测定血清脂质水平和载脂蛋白谱，分析冠心病合并MS患者血脂的特点。结果与未合并MS组比较，冠心病合并MS组甘油三酯(TG)、载脂蛋白B (ApoB)、载脂蛋白C₂(ApoC₂)、载脂蛋白C₃(ApoC₃)水平均增高(P<0.05～0.01)；高密度脂蛋白胆固醇(HDL-C)、载脂蛋白A₁(ApoA₁)水平低于未合并MS组(P<0.05～<0.01)；两组冠心病患者总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A₂(ApoA₂)、载脂蛋白E (ApoE)水平比较无统计学差异(P>0.05)；冠心病合并MS组冠脉病变严重程度明显增加(P<0.01)。结论冠心病患者合并MS存在多种脂质代谢紊乱，并可加重冠状动脉病变严重程度。

Abstract: Objective To analyze the serum levels of lipid and apolipoprotein (Apo) in coronary heart disease (CHD) patients with metabolic syndrome (MS). Methods One hundred and nineteen CHD patients, who underwent coronary arteriography in our hospital from May 2011 to October 2012, were divided into CHD with MS group (n=53) and CHD without MS group (n=66).Risk factors for CHD were compared between the two groups.Their serum levels of lipid and Apo were measured.Characteristics of lipid prof ile in CHD patients with MS were analyzed. Results The serum levels of TG, ApoB, ApoC₂ and ApoC₃ were signif icantly higher whereas that of HDL-C and ApoA₁ were signif icantly lower in CHD with MS group than in CHD without MS group (P< 0.05-< 0.01).No signif icant difference was found in TC, LDL-C, ApoA₂ and ApoE between the two groups (P> 0.05).The coronary artery lesion was severer in CHD with MS group than in CHD without MS group (P< 0.01). Conclusion CHD patients with MS suffer from multiple lipid metabolic disorders which can aggravate their coronary artery lesions.

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