Abstract: Objective To assess the left ventricular systolic function of type 2 diabetes mellitus(DM) patients with 3-dimensional ultrasound speckle tracking imaging(3D-STI). Methods Forty type 2 DM patients served as a DM group and 40 healthy volunteers served as a control group in this study.3D-STI was recorded from standard left ventricular apical 4-chamber views.Left ventricular end-diastolic volume(LVEDV),left ventricular end-systolic volume(LVESV),left ventricular ejection fraction(LVEF),and left ventricular global longitudinal peak systolic strain(LVGLS),left ventricular global radial peak systolic strain(LVGRS),left ventricular global circumferential peak systolic strain(LVGCS),left ventricular global area peak systolic strain(LVGAS) in the two groups were measured and compared.Their correlation was analyzed. Results The LVEDV,LVESV were higher in diabetes groups than in normal controls,and the LVEF were lower in diabetes groups than in normal controls(P<0.05);The LVGLS were significantly lower in diabetes groups than in normal controls(P<0.01),The LVGRS,LVGCS and LVGAS were lower in diabetes groups than in normal controls(P<0.05);The LVGLS,LVGRS,LVGCS and LVGAS were significantly correlated with LVEF in type 2 diabetes mellitus patients and normal controls. Conclusion 3D-STI can accurately assess the left ventricular global systolic function of type 2 DM patients.