Abstract: Objective To provide the evidence for the prevention and treatment of pulmonary embolism by studying its main pathogenic factors. Methods Clinical data(including demographic features, risk factors, concomitant diseases and prognosis) about 282 pulmonary embolism patients admitted to our hospital in recent 5 years were analyzed. Results Of the 282 pulmonary embolism patients included in this study, 232 with their age ≥ 36 accounted for 82.27%. The main pathogenic factor was lower extremity deep vein thrombus(DVT) in 124 patients(43.97%), followed by operation wound within 3 months in 92(32.62%), malignant tumor in 49 patients(17.38%) and history of pulmonary embolism in 35 patients(12.41%). Conclusion It is important to prevent pulmonary embolism in ≥ 36 years old patient with lower extremity DVT, operation wound within 3 months, malignant tumor and history of pulmonary embolism.