Abstract: Objective To study the safety and efficiency of rapamycin-eluting stent in coronary heart disease (CHD) patients after intervention therapy. Methods Two hundred and sixty-nine CHD patients who underwent coronary arteriography and rapamycin-eluting stent implantation in our department from January 1, 2009 to November 1, 2011 were randomly divided into 1-year follow-up group (n=130) and 3-year follow-up group (n=139). Their major adverse cardiovascular events (MACE) and target vessel revascularization (TVR) after rapamycin-eluting stent implantation were observed by coronary arteriography. Results The total incidence of MACE and TVR was significantly lower in 1-year follow-up group than in 3-year follow-up group (3.25% vs 13.28%， P=0.04; 2.44% vs 8.59%， P=0.03) while no significant difference was observed in the incidence of cardiac death and non-fatal myocardial infarction between the two groups (0.81% vs 2.34% and 0.00% vs 2.34%， P=0.64， P=0.26). Coronary arteriography showed that the incidence of restenosis was significantly lower in 1-year follow-up group than in 3-year follow-up group (9.4% vs 20%， P=0.02). Conclusion The incidence of TVR and restenosis is higher in 3-year follow-up group than in 1-year follow-up group after rapamycin-eluting stent implantation.