Abstract: Objective To study the consistency of different curative effect assessment criteria for liver metastasis of colon cancer. Methods Clinical data about 68 patients with surgery and biopsy-confirmed liver metastasis of colon cancer admitted to our hospital from 2010 to 2012 were retrospectively analyzed. The patients underwent enhanced multi-slice spiral CT scanning 2 weeks before and 6 weeks after treatment, respectively. The curative effect for solid tumor was assessed according to the WHO, RECIST1.0, and RECIST1.1 criteria using the Siemens software. Results Spearman correlation analysis showed that the coeffcient for the WHO and RECIST1.0 criteria, RECIST1.1 criteria, and RECIST1.1 criteria was 0.834, 0.827, and 0.843, respectively (P＜ 0.05). Conclusion The consistency of WHO, RECIST1.0 and RECIST1.1 criteria is quite good. However, the RECIST1.1 criteria are more suitable for the curative effect assessment in patients with liver metastasis of colon cancer.