人类白细胞抗原-G5对移植肾功能延迟恢复的影响

Effect of HLA-G5 on delayed graft function of kidneys

摘要: 目的观察和比较人类白细胞抗原-G5(human leukocyte antigen G5，HLA-G5)不同表达水平对肾移植术后移植肾功能延迟恢复(delayed graft function，DGF)的影响。方法应用酶联免疫方法(ELISA)检测HLA-G5在肾移植受者体内表达情况，分析对比HLA-G5不同表达组移植肾功能延迟恢复的发生率。结果肾移植术后HLA-G5高表达组无1例发生DGF，而低表达组发生率为57%(P＜ 0.05)。结论 DGF的发生与HLA-G5表达水平密切相关，HLA-G5可能通过减少排斥反应减少DGF的发生。

Abstract: Objective To study the effect of HLA-G5 expression levels on delayed graft function (DGF) of kidneys． Methods Expression levels of HLA-G5 in kidney transplantation recipients were measured by ELISA． Effects of HLA-G5 expression levels on DGF of kidneys were comparatively analyzed． Results DGF did not occur in any kidney transplantation recipient with a high HLA-G5 expression level． However, the incidence of DGF was 57% in those with a low HLA-G5 expression level (P＜ 0．05)． Conclusion DGF is closely related with HLA-G5 expression level in kidney transplantation recipients． HLA-G5 can reduce the incidence of DGF by decreasing the reject reaction．