Abstract: Objective To improve the understanding of the imaging features of ectopic pancreas of duodenum by summarizing its CT findings. Methods Clinical data and imaging features of 2 patients with ectopic pancreas of duodenum admitted to our hospital from October 2013 to November 2013 were retrospectively analyzed. Results The 2 male patients were 33 and 41 years old respectively. They had upper abdominal pain with unknown reasons. One was accompanied with radiation backache and occasional abdominal distension while the other was accompanied with vomiting and nausea. CT scanning showed that the lesion involved the descending duodenum wall, which manifested as irregular thickening of the duodenum wall and stenosis of the duodenum cavity, with a tubular cystic density shadow in the foci and dilated pancreatic and common bile ducts. The parenchyma of lesion was significantly enhanced at the conventional arterial and venous phases, which was similar to the enhanced pancreatic parenchyma. However, there showed no enhancement of the cystic part of pancreas. The density in parenchyma of pancreatic head was uneven and the fatty space was unclear around the duodenum. Conclusion Ectopic pancreas of duodenum can be diagnosed according to its certain characteristics detected by CT scanning in combination with its clinical history.