Abstract: Objective To investigate the curative effect of continuous blood purification (CBP) on prognosis of patients with severe sepsis. Methods Clinical data about 60 patients with severe sepsis in ICU from January 2010 to January 2014 were retrospectively analyzed. These patients were divided into two groups: CBP group (n=30) and the control group (n=30). Patients in the control group received conventional therapy while in CBP group continuous blood purification was added. 28-day survival rate as well as the changes of haemodynamics and inflammatory factors before and 72 h after therapy were analyzed between these two groups. Results There were remarkable amendment in mean arterial blood pressure, heart rate and oxygenation index (PaO₂/FiO₂) in patients of CBP group (P＜0.05). Compared with those in the control group, the c-reactive protein, procalcitonin, interleukin-6, brain natriuretic peptide and serum lactic acid significantly decreased in CBP group (P＜0.05), while the oxygenated index increased greatly (P＜0.05). Although the acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ) decreased significantly in CBP group compared with those in the control group (P＜0.05), there was no obvious difference in 28-day survival rate between these two groups (P=0.286). Conclusion The therapy of CBP can remove inflammatory factors, keep haemodynamics stable and improve oxygenated function effectively in patients with severe sepsis. However, its effects on survival rate still need to be proved in the further study.