Abstract: Objective To investigate the effcacy of local periarticular injections of analgesic drugs for primary bilateral total knee arthroplasty (TKA). Methods Forty patients (80 knee-joint lesions) with severe osteoarthritis (OA) who underwent TKA in our hospital from July 2013 to March 2014 were enrolled in this study. The right knees were given local periarticular injections of analgesic drugs (injection group, n=40) according to left knee frst and then right knee, while the left knees were not injected in the control group (n=40). The VAS scores, the range of motion and adverse effects were recorded. Results The postoperative rest VAS scores at 6 h to 36 h between two groups had statistical signifcance (P< 0.05). The postoperative motional VAS scores at 12 h were lower in injection group than in control group (P< 0.05). The knee joint range of motion at 24 h were better in injection group than in control group (P< 0.05). No infection was found in these 40 patients. Conclusion Local periarticular injections of analgesic drugs can obviously improve the short-term pain control and the knee joint range of motion to patients undergoing TKA.