Abstract: Objective To study postoperative prognosis and related factors of pulmonary wedge resection for primary non-small cell lung cancer （NSCLC）. Methods A retrospective analysis was conducted for patients with NSCLC admitted to thoracic surgery department who had undergone pulmonary wedge resection due to pulmonary insufficiency， cardiac insufficiency or other factors from January 2007 to June 2013 in our hospital were included in this group， those patients with signs of suspicious metastasis or pure ground glass opacity （PGGO） were excluded. Postoperative treatment and overall survival were included in the follow up items. The Kaplan-meier method was used for univariate analysis of independence prognostic factors， while Cox model was used for multivariate analysis of prognostic factors. Results Totally 108 patients were enrolled in the group with 3-year and 5-year overall survival rate of 63.0% and 31.7%， respectively. The pathological type and tumor T-staging were independent factors of overall survival in univariate analysis （P＜ 0.05）. However， in multivariate analysis， T-staging was the only prognostic factors （P＜ 0.01）. Conclusion For those NSCLC patients with high perioperative risk, wedge resection is an effective treatment and the prognosis of patients is related to tumor T-staging.