Abstract: DNA methylation is a long-term and stable epigenetic modification of genes， which can regulate the expression of gene through changing the ability of DNA in combining with transcription apparatus. Cardiovascular diseases are the main diseases that endanger human's health， up to now the pathogenesis of cardiovascular diseases is still not clear. This review focuses on the role of DNA methylation in major cardiovascular diseases such as hypertension， coronary artery disease， heart failure and so on， which will help us to understand such diseases and will lead to new approaches to the prevention and clinical treatment of them.