Abstract: Objective To summarize the experience of treatment in one adult patient with Ebola virus disease in western Africa. Methods A 56-year old male health worker, who had contacted a patient with Ebola virus disease in local, was sent to the China Ebola Treatment Unit, Liberia, on day 3 after symptom onset. The patient was diagnosed as confrmed Ebola virus disease on day 4 and received supportive treatment, including intravenous fuid infusion, enteral nutrition, antibiotics, pyretolysis, antidiarrheal. Results The patient died after 7-day routine supportive treatment. Conclusion This case shows the challenges in the treatment of severe Ebola virus disease and suggests that we need to use modern technology, critical monitoring and therapy to save lives of patients with severe infectious disease.