Abstract: Objective To observe the therapeutic effect of manipulation combined with exercise therapy treatment for patients with emporomandibular disorders (TMD). Methods Sixty patients with TMD treated in our hospital from December 2013 to February 2015 were enrolled and they were randomly divided into control group (n=30) and treatment group (n=30), the control group were reated with transcutaneous electrical nerve stimulation (TENS) and ultrashort wave, while the treatment group were treated with soft issue mobilization, joint mobilization combined with exercise therapy. After 2 weeks of treatment, the maximum mouth opening MMO) and visual analogue scale (VAS) score of two groups were compared. Results After 2 weeks of treatment, the MNO and VAS score of patients in two groups were improved, the MMO in treatment group were significantly higher than control group (36.86±4.76) mm vs (34.10±4.27) mm, P＜ 0.05, the VAS score in treatment group were not signifcantly higher than control group (1.30±0.99) vs (1.40±0.81), P＞ 0.05. Conclusion TENS and ultrashort wave therapy, physiotherapy and manipulation ombined with exercise therapy can alleviate pain and improve the limitation of mouth opening in patients with temporomandibular disorders, while manipulation combined with exercise therapy for the catter shows more signifcant clinical effects.