Abstract: Objective To analyze the relationship between epicardial adipose tissue and left ventricular function by multi-slice spiral CT (MSCT) in coronary heart disease patients. Methods Sixty-five cases with suspected coronary disease were given CTA inspection in our hospital from December 2014 to May 2015. As the inclusion criteria, left ventricular function parameter values of 65 patients were measured, including end systolic volume (ESV), end diastolic volume (EDV), stroke volume (SV), ejection fraction(EF), cardiac output (CO) and myocardial mass (MM). EAT volume were detected by GEAW 4.5 workstation. Results EAT volume and GS score had positive correlation (r=0.555). There were significant differences between two groups excluding mild and moderate stenosis. GS score was positively correlated with ESV, EDV, MM (r=0.45, 0.37, 0.44), and it was negatively correlated with EF(r=0.33), but it had no significant correlation with SV and CO. EAT volume was positively correlated with ESV, EDV, MM (r=0.26, 0.26, 0.29), but it had no significant correlation with SV, EF and CO. Conclusion MSCT can measure EAT volume and analyze its correlation with left ventricular function, which provides new references for early diagnosis and treatment of coronary heart disease.