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哈斯, 郭玲玲, 谷伟军, 窦京涛, 杨国庆, 金楠, 陈康, 杜锦, 臧丽, 杨丽娟, 郭清华, 巴建明, 吕朝晖, 母义明. 273例肌酸激酶增高的内分泌疾病病因构成分析[J]. 解放军医学院学报, 2015, 36(12): 1165-1168. DOI: 10.3969/j.issn.2095-5227.2015.12.001
引用本文: 哈斯, 郭玲玲, 谷伟军, 窦京涛, 杨国庆, 金楠, 陈康, 杜锦, 臧丽, 杨丽娟, 郭清华, 巴建明, 吕朝晖, 母义明. 273例肌酸激酶增高的内分泌疾病病因构成分析[J]. 解放军医学院学报, 2015, 36(12): 1165-1168. DOI: 10.3969/j.issn.2095-5227.2015.12.001
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HA Si, GUO Lingling, GU Weijun, DOU Jingtao, YANG Guoqing, JIN Nan, CHEN Kang, DU Jin, ZANG Li, YANG Lijuan, GUO Qinghua, BA Jianming, LYU Zhaohui, MU Yiming. Clinical characteristics of endocrine diseases with increased creatine kinase[J]. ACADEMIC JOURNAL OF CHINESE PLA MEDICAL SCHOOL, 2015, 36(12): 1165-1168. DOI: 10.3969/j.issn.2095-5227.2015.12.001
Citation: HA Si, GUO Lingling, GU Weijun, DOU Jingtao, YANG Guoqing, JIN Nan, CHEN Kang, DU Jin, ZANG Li, YANG Lijuan, GUO Qinghua, BA Jianming, LYU Zhaohui, MU Yiming. Clinical characteristics of endocrine diseases with increased creatine kinase[J]. ACADEMIC JOURNAL OF CHINESE PLA MEDICAL SCHOOL, 2015, 36(12): 1165-1168. DOI: 10.3969/j.issn.2095-5227.2015.12.001
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273例肌酸激酶增高的内分泌疾病病因构成分析

Clinical characteristics of endocrine diseases with increased creatine kinase

    摘要
  • 摘要: 目的 总结住院内分泌疾病患者肌酸激酶升高的程度和症状，分析内分泌疾病肌酸激酶升高病因构成和特点。 方法 收集2008年1月1日- 2014年1月1日解放军总医院肌酸激酶增高的内分泌科住院患者的临床资料，包括性别、年龄、临床诊断、激酶升高程度，相关症状等并进行病因构成及临床特点分析。 结果 肌酸激酶明显增高的内分泌疾病病因构成比由高到低顺序：糖尿病未合并急性并发症(33.7%，其中合并糖尿病肾病15%)，低血钾性疾病(20.5%)，垂体前叶功能减退(16.5%)，糖尿病合并急性并发症(12.5%，酮症酸中毒为主)，原发性甲状腺功能减退(7.0%)，甲状旁腺功能减退(5.9%)，其他(4%)；35.5%患者有轻微神经肌肉症状，有症状者肌酸激酶较对照组增高(P=0.000)；97.1%患者预后良好。 结论 对于住院内分泌疾病患者，糖尿病肾病及糖尿病酮症酸中毒是糖尿病患者肌酸激酶增高最常见原因，非糖尿病患者有低血钾性疾病、垂体前叶功能减退、原发甲状腺功能减退症、甲状旁腺功能减退症时肌酸激酶增高发生率较高。多数患者无典型神经肌肉症状，预后良好。

     

    Abstract: Objective To analyze the different reasons and characters which cause the increase of creatine kinase (CK) in patients with endocrine disease． Methods Clinical data about 273 cases characterized as high CK from January 1, 2008 to January 1, 2014, including gender, age, diagnosis, CK level and relevant symptoms, were analyzed． Results The percentage of endocrine reasons which caused CK increase were listed below from high to low: diabetes without acute complication (33．7%) (diabetes with kidney disease accounting for 15%), hypokalemia related diseases (20．5%), function decrease in the frontier lobe of pituitary (16．5%), diabetes with acute complication (12．5%) (most patients had ketoacidosis), primary hypothyroidism (7．0%), hypoparathyroidism (5．9%), others (4%)． Patients had mild neural muscle symptoms accounting for 35．5%, and they showed higher CK level compared to the control group (P=0．000)． 97．1% of patients were cured without adverse outcomes． Conclusion For hospitalized patients with endocrine disease, the most common reasons which cause high CK in diabetes are diabetes kidney disease or diabetic ketoacidosis (DKA)． Patients without diabetes show higher rate in the presence of hypokalemia related diseases, anterior hypopituitarism and primary hypothyroidism, hypoparathyroidism． Most patients have no typical neural muscle symptoms and show good prognosis．

     

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