Abstract: Objective To investigate the related risk factors for intra-abdominal infection in patients with pancreatic carcinoma after operation． Methods Clinical data about 318 pancreatic carcinoma patients underwent operation in Chinese PLA General Hospital from January 2010 to December 2014 according to the inclusion criteria were retrospectively analyzed． The patients were divided into two groups according to intra-abdominal infection after operation: infection group (n=19) and control group (n=299)． The general data, operation situation and postoperative complications data were statistical analyzed． Results All patients had completed the operation successfully, and intra-abdominal infection occurred in 19 cases with incidence rate of 5．97% (19/318)． Multivariate analysis of 13 clinical indexes showed that blood transfusion, pancreatic fistula, biliary fistula were independent risk factors of intra-abdominal infection (P< 0．05)． Conclusion The intra-abdominal infection rate is high in pancreatic carcinoma patients after operation． The blood transfusion, pancreatic fistula and bile fistula are the main risk factors．