Abstract: Long noncoding RNA (lncRNA) is defined as non-protein-coding transcript which is larger than 200 nt． lncRNA participates in regulating various important biological processes, such as X chromosome silencing, imprinting genome, cell development and differentiation and so on, and its expression disorder is associated with the development of a variety of human diseases． Recent evidences have shown that lncRNA plays a key role in the differentiation and activation of immune cells and its changed expression in immune-related diseases is correlated with the development, progression and prognosis of these diseases． This article focuses on related information about lncRNA and its impact on the regulation of immune-related diseases, especially in innate immunity．