Abstract: Objective To investigate the incidence rate of catheter-related thrombosis in senile patients with 4 kinds of catheterization positions: subclavian vein, femoral vein, jugular vein and PICC, provide guidance for the prevention of catheter-related thrombosis. Methods Seven hundred and seventeen hospitalized senile patients with central venous catheterization in geriatric department of Chinese PLA General Hospital from January 2008 to December 2012 were selected.Retrospective investigation and analysis were carried out on general conditions, basic diseases, clinical characteristics and incidence of catheter-related thrombosis. Results Of the 717 patients, 69 cases(9.62%)were diagnosed with catheter-related thrombosis.The incidence rate of catheter-related thrombosis in subclavian vein group was lower than femoral vein group(3.27% vs 16.67%, P＜0.01)and PICC group(3.27% vs 12.72%, P＜0.01), and it was also lower than jugular vein group(3.27% vs 10.81%, P＜0.05).No difference was found between femoral vein, PICC, and jugular vein group(P＞ 0.05). Conclusion Subclavian vein catheterization is the best choice for senile patients.PICC can be used in patients with specialized diseases, while some measures should be reinforced to prevent thrombosis.