Abstract: Objective To study the anesthetic management of difficult airway caused by huge head and neck neoplasms in children. Methods Clinical data about three surgeries of a 2-year old child with temporal bone rhabdomyosarcoma who was hospitalized on June 14, 2014 were reviewed and the anesthetic features and clinical treatment principles of difficult airway caused by huge and neck neoplasms in children were retrospectively analyzed. Results The patient underwent three surgeries successively on June 24, July 15 and September 4 in 2014.Because of difficult airway resulting from huge and pharynx oralis-involved tumor, the operation plan was changed from implantable venous-access ports under general anesthesia to right subclavian vein catheterization under local anesthesia with inhalation anesthesia of sevoflurane in the second surgery.Three operations were all uneventful. Conclusion It suggests that children with huge head and neck neoplasms cannot adopt rapid induction and tracheal intubation blindly, anesthesia procedure should be undertaken gradually and make viable and secure anesthesia program.