Abstract: Objective To investigate the efficacy of thrombus aspiration combined with triofiban in the treatment of patients with acute ST-segment elevation myocardial infarction (STEMI). Methods From March 2011 to May 2015, 326 patients with acute ST segment elevation myocardial infarction in our hospital were randomlydivided into experimental group (n=168) and control group (n=158). Patients in experimental group were treated with thrombus aspiration combined with triofiban on the basis of conventional percutaneous coronary intervention (PCI), while patients in control group were treated with conventional PCI. The efficacy, postoperative cardiac function indices and major adverse cardiac events (MACE) of patients in two groups were analyzed. Results The number of vascular lesions in experimental group was significantly higher than control group (χ²=4.739, P=0.029). There were no significantdifferences in age, sex, smoking history, diabetes history between two groups (P> 0.05). Creatine kinase (CK) levels, creatine kinase isoenzyme (CK-MB) level, CK peak time, CK-MB peak time and no reflow incidence of experimental group were significantly lower than control group (1 255.72±368.53) U/L vs (1 852.35±326.48) U/L, (113.42±26.80) U/L vs (225.82±25.96) U/L, (9.37±3.74) h vs (12.95±7.46) h, (9.41±3.68) h vs (12.66±6.82) h and 1.2% vs 5.1%. Proportions of TIMI (thrombolysis in myocardial infarction) grade 3 and TMP (TIMI myocardial perfusion) grade 3 of experimental group were significantly higher than those of control group (91.1% vs 72.2%, and 92.9% vs 82.9%). The number of rehospitalized patients at 1 month after operation in experimental group was significantly less than control group (χ²=11.498, P=0.001). There were no significantdifferences between two groups in totaldeath, reinfarction and revascularization (P> 0.05). At three months and six months after operation the percentages of rehospitalized patients (23.8% and 32.1%), totaldeath (4.2% and 5.4%), reinfarction (1.2% and 1.8%) and reascularization (1.2% and 1.8%) of experimental group showed a reducing tendency compared with control group (25.9% and 35.4%, 6.3% and 10.1%, 7.0% and 10.8%, 2.5% and 4.4%, 1.3% and 3.8%). Conclusion PCI combined with thrombus aspiration and tirofiban therapy are more effective than the conventional PCI therapy, which reduces thrombus burden, increaseseffective myocardial perfusion and improves the prognosis of patients with STEMI.