Abstract: Objective To evaluate the clinical efficacy of noninvasive positive pressure ventilation (NIPPV) in the treatment of severe bronchial asthma. Methods Sixty patients who were diagnosed as severe bronchial asthma admitted to our hospital were selected as the research sample, and they were randomly divided into study group (n=30) and control group (n=30). Patients in control group were administrated with conventional treatment, while patients in study group received noninvasive positive pressure ventilation treatment and conventional treatment. Blood gas analysis was performed before and after treatment for all the patients. Results There was significant difference in blood gas analysis (pH, PO₂, PCO₂, SO₂) before and after treatment in both two groups (P＜ 0.05). The total effective rate was 96.7% in study group and 86.7% in control group with statistically significant difference (P＜ 0.05). Conclusion Noninvasive positive pressure ventilation is a safe and effective treatment which can improve blood gas indexes in patients with severe bronchial asthma.