Abstract: Objective To investigate the clinical features, diagnosis and treatment of synchronous multiple primary colorecta carcinomas. Methods Clinical data about patients with synchronous multiple primary colorectal carcinomas admitted to our hospita from January 2009 to March 2015 were retrospectively analyzed. Results A total of 28 patients with synchronous multiple primary colorectal carcinomas were recruited including 16 males and 12 females with average age of 59.85 years. There were 19 case with double primary malignancies, 6 cases with triple primary malignancies and 3 cases with quadruplex primary malignancies Adenocarcinoma was the main pathologic type. Twenty-three cases were confirmed by electronic colonoscopy before operation, and 5 cases through supplementary diagnosis during operation or postoperative pathological examination. All patients received first stage surgical treatment. Twenty-seven patients received radical resection and one received palliative resection. Overall survivals were 22 out of 24 in 1-year follow-up, 17 out of 19 in 2-year follow-up, 10 out of 13 in 3-year follow-up, and 4 out of 5 in 5-year followup. Conclusion Synchronous multiple primary colorectal carcinomas are not so prevalent in clinical practice. They have unique epidemiological characteristics. It suggests that comprehensive and detailed electronic colonoscopy examination before operation and exploration during operation should be emphasized. Suspected malignant lesions which cannot be completely excluded by preoperative biopsy, should be subjected to intraoperative frozen section examination. Making rational operation plan according to the location and scope of the tumor lesions as well as personalized radiotherapy and chemotherapy regimen can contribute to reducing postoperative relapse and improve overall survival rate of patients with synchronous multiple primary colorectal carcinomas.