Abstract: Prostate transmembrane protein (PMEPA1) is a tumor-associated protein-encoding gene found in recent years, which can be directly induced by androgen and TGF-β(Transforming growth factor β). Further studies shows that PMEPA1 is abnormally expressed in prostate cancer, breast cancer, prostate cancer, lung cancer and other types of tumor. PMEPA1 has been confirmed to be involved in the regulation of multiple signaling pathways and has an important impact on the proliferation, invasion, metastasis and other biological behavior of malignant tumor cells. PMEPA1 can also be a prognostic factor for patients with malignant tumors. In this paper, the research progresses about the structure, gene expression, biological function and related regulatory mechanisms of PMEPA1 will be reviewed.