Abstract: Psoriasis is a chronic inflammatory skin disease, and metabolic syndrome is a combination of central obesity, dyslipidemia, glucose intolerance and elevated blood pressure. Many epidemiological surveys have revealed the association between psoriasis and metabolic syndrome. These evidences suggest the presence of each of the two diseases may promote the progression of the other. Herein, we review the association between psoriasis and metabolic syndrome, the possible mechanism of mutual effect of these two diseases, and suggestion for clinical practice of dermatologists.