CUE结构域2表达与结直肠癌淋巴结转移的关系探讨

胡时栋; 胡子龙; 邹贵军; 吴有军; 邢晓伟; 李宇轩; 张凯; 何长征; 王迪; 杨宇; 王玉锋; 杜晓辉

doi:10.3969/j.issn.2095-5227.2017.05.003

CUE结构域2表达与结直肠癌淋巴结转移的关系探讨

Relationship between the expression of CUE domain-containing 2 and lymph nodes metastasis in colorectal cancer

摘要

摘要: 目的探讨CUE结构域2(CUE domain-containing 2，CUEDC2)表达与结直肠癌淋巴结转移的关系。方法收集2015年12月-2016年5月在我院住院手术的153例结直肠癌患者的临床资料与癌组织蜡块，使用免疫组化方法分析CUEDC2的表达，对CUEDC2与结直肠癌淋巴结转移的关系进行单因素及多因素分析。结果结直肠癌淋巴结转移患者CUEDC2免疫组化评分明显高于无淋巴结转移患者(7.41±1.46 vs 4.61±1.27，P<0.05)。多元Logistic回归分析结果表明，高CUEDC2免疫组化评分是结直肠癌发生淋巴结转移的独立危险因素。结论 CUEDC2免疫组化评分≥8分与结直肠癌淋巴结转移相关，CUEDC2可能对结直肠癌淋巴结转移起到促进作用。

Abstract: Objective To analyze the relationship between the expression of CUE domain-containing 2 (CUEDC2) and lymph nodes metastasis in colorectal cancer. Methods Clinical data and paraffinsections of 153 patients with colorectal cancer who underwent operation in Chinese PLA General Hospital from December 2015 to May 2016 were collected. The expression of CUEDC2 was analyzed by immunohistochemistry assay and univariate and multivariate analyses were carried out to investigate the association of the expression of CUEDC2 with lymph nodes metastasis. Results The immunohistochemical score of CUEDC2 in cases with lymph nodes metastasis of colorectal cancer was significantly higher than those without metastasis (7.41±1.46 vs 4.61±1.27, P< 0.05). Multivariate logistic regression analysis revealed that high immunohistochemical score of CUEDC2 was independent risk factor for lymph nodes metastasis in CRC patients (OR:4.777, 95% CI:2.827-8.071, P< 0.05). Conclusion High CUEDC2 immunohistochemical score (≥ 8) is correlated with lymph nodes metastasis in colorectal cancer and CUEDC2 probably promotes the metastasis.

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