Abstract: Immune imbalance is the main characteristic in sepsis pathophysiological process, while immunosuppression is an important cause of opportunistic infections and death. As primary components of immune response, human leukocyte antigen (HLA -DR), TNF-α, IL-6 and IL-10 play key roles in antigen presentation, innate and adaptive immune system activation, and immune regulation, and the concentration and changing trend of these indicators in plasma are of great prognostic and predictive significance in sepsis.