软骨干细胞修复软骨损伤及治疗骨关节炎的研究进展

Research advance of cartilage-derived stem/progenitor cell in cartilage repair and its therapeutic potential in osteoarthritis

摘要: 软骨损伤通常导致整个关节的病变，从而诱发骨性关节炎。目前已证实关节软骨中存在一类具有自我增殖性、表面抗原表达特性及多向分化潜能的软骨干细胞，该类细胞可以自发聚集到损伤部位进行修复，有利于快速构建软骨修复的微环境。但软骨干细胞的起源和功能尚需进一步明确。本文就软骨干细胞在软骨损伤修复中的作用及对骨性关节炎的治疗等研究进展进行综述。

Abstract: Articular cartilage is a physiologically non-self-renewing avascular and nerveless tissue． Injury to cartilage often involves the whole joint, leading to development of degenerative joint diseases such as osteoarthritis (OA)． Articular cartilage has been shown to contain a population of so-called cartilage-derived stem/progenitor cells (CSPCs), which are characterized by stem-cell related surface markers, clonogenicity and multilineage differentiation ability． The CSPCs are spontaneously aggregated and migrated to the damaged region to reconstruct the local microenvironment for repair． However, the origin and functions of CSPCs still remain unclear． Here we review the current status of CSPC research and discuss the possible role of cartilage stem cell may have in cartilage repair, and its therapeutic potential in OA．