Abstract: Objective To investigate the clinical effect of cement-augmented pedicle screw (CPS) for the treatment of multiple spinal diseases with osteoporosis. Methods A total of 249 cases were selected from May 2013 to August 2016 for posterior spinal surgery in our department. Patients in observation group (n=83) underwent cemented pedicle screws (CPS) to strengthen fixation, while the control group (n=166) underwent traditional pedicle screw fixation. The basic information, indicators of surgery, clinical outcomes and radiological parameters were recorded before and after surgery, and comparative analysis was performed between the two groups. Results There was no statistical difference in age, gender and preoperative bone mineral density between the two groups (all P> 0.05). The operating time in observation group was significantly longer than that in control group(4.0 ± 0.6) h vs (3.1±0.6) h, P=0.023). There was no statistical difference in other surgical indexes. In terms of clinical results, there was no statistical difference between observation group and control group before and at 3 months after operation. However, at 12 months after operation, the VAS score and ODI score in the observation group were both lower than those in control groupVAS:(1.6±0.7) vs (2.4±0.5); ODI:(21.0±5.3) vs (31.5±6.9); P< 0.05, respectively). Long-term results of degenerative scoliosis and kyphosis measured by radiological parameters at 12 months after surgery were better in observation group than those in control group (all P< 0.05). Conclusion CPS is safe and effective for the treatment of multiple spinal degenerative diseases with osteoporosis, and it can achieve satisfactory long-term results.