Abstract: Objective To compare the safety and perioperative parameters of 3D laparoscopy versus traditional open surgery for liver metastasis of colorectal cancer. Methods Clinical data about 116 cases who had undergone colorectal liver metastases resection in Chinese PLA General Hospital from May 2012 to May 2017 were retrospectively analyzed. The patients were divided into observation group and control group according to their different operating methods. Patients in observation group (n=57) received 3D laparoscopy, and control group (n=59) received traditional open surgery. The safety and perioperative parameters were evaluated and compared. Results There was no statistically significant difference between the two groups in baseline data, such as age, gender, BMI and pathological type. The operating time(164.32±18.61) min vs (184.21±22.01) min, P=0.001, intraoperative blood loss volume(72.23 ±16.44) ml vs (82.32±18.74) ml, P=0.002, incision length(7.35±1.61) cm vs (17.34 ±2.43) cm, P=0.001, time to ambulation(1.3±0.6) d vs (2.2±0.8) d, P=0.001 and length of hospitalization(8.1±1.6) d vs (9.3±2.1) d, P=0.002 in the observation group were all significantly less than those of control group. In observation group, biliary fi stula occurred in 4 cases, incisional infection in 3 cases and hemorrhage in 4 cases. While in control group, biliary fi stula occurred in 5 cases, abdominal infection in 5 cases and hemorrhage in 4 cases, all of which were cured and discharged after symptomatic treatment, while the difference in incidence of postoperative complications between two groups was not significant (P=0.208). Conclusion Compared with traditional open surgery, the 3D laparoscopic surgery is more safe, feasible for colorectal carcinoma with liver metastasis.