Abstract: Objective To provide evidences for diagnosis of orbital space-occupying lesions by analyzing their histopathologic classification and clinical features. Methods Clinical data about patients with orbital occupying lesions who underwent surgery in Chinese PLA General Hospital from April 2013 to March 2018 were retrospectively analyzed. Results There were 156 cases(74 males and 82 females) with average age of (37.2±4.4) years included in our study. Of the 156 cases, 120 (76.92%) cases had benign orbital diseases, and the top 3 benign orbital diseases were cavernous hemangioma (45 cases, 28.85%), (epidermoid) dermoid cyst (16 cases, 10.26%) and inflammatory pseudotumor (12 cases, 7.69%); 36 (23.07%) cases had malignant tumors, and the top 3 diseases were lymphoma (18 cases, 11.54%), lacrimal gland adenoid cystic carcinoma (5 cases, 3.21%), and secondary tumors (4 cases, 2.56%). The most frequent causes of visit were proptosis (48.72%), palpable masses (15.38%) and visual acuity attenuation(12.82%). Conclusion There are enormous kinds of orbital space occupying lesions. Cavernous hemangioma and lymphoma are the most common seen benign and malignant orbital occupying lesions, respectively.